What is FamilialAdenomatous Polyposis?
Familial Adenomatous Polyposis is a genetic condition. It is
diagnosed when a person develops more than 100 adenomatous colon polyps. An
adenomatous polyp is an area where normal cells that line the inside of a
person’s colon form a mass on the inside of the intestinal tract. On average, polyps develop in people with FAP is in their mid-teens. Most people
with FAP will have multiple colon polyps by age 35. If FAP is not recognized
and treated, there is a very high likelihood that a person will develop
colorectal cancer.
Individuals with FAP also have an increased chance of
developing cancer in other organs, including the stomach, small intestine, and pancreas, and biliary tree. The risk for hepatoblastoma, a type of liver cancer,
is increased in children with FAP. Desmoid tumors/desmoid fibromatosis, a
locally aggressive tumor that does not spread (metastasize), and a type of
brain tumor called medulloblastoma can also occur in some individuals. The risk for
papillary thyroid cancer is also increased,
What are all symptoms
of Familial Adenomatous Polyposis?
Not all symptoms of FAP are cancer-related. Some additional
features of FAP may include: osteomas (noncancerous bony growths, usually found
on the jaw), extra, missing, or unerupted teeth, congenital hypertrophy of the
retinal pigment epithelium (CHRPE), which is an eye condition that is present
at birth that does not affect vision, but it is a condition that an eye the physician may see during an examination with a special instrument called an ophthalmoscope.
Benign (noncancerous) skin changes, such as epidermoid cysts and fibromas and
adrenal masses are also typical symptoms of FAP.
What are the FamilialAdenomatous Polyposis Market Report Types?
There are four subtypes of familial adenomatous polyposis,
namely, Classic familial adenomatous polyposis, Attenuated familial adenomatous
polyposis (AFAP), Gardner syndrome, and Turcot syndrome.
Familial adenomatous polyposis is caused by changes in a gene
known as APC. About 20% to 25% of people with FAP have a new APC mutation that
did not come from a parent. People with AFAP have fewer polyps in the large and
small intestines, usually no more than 30 by the time they are adults while
people with Classic familial adenomatous polyposis, Gardner syndrome and Turcot the syndrome usually develop at least 100 polyps, but usually many more, in the
large and small intestines by the time they are adults.
Most participants who went under surgery for the treatment
of FAP expressed unmet needs, such as lack of healthcare providers with good
knowledge about FAP, practical and psychosocial support, FAP educational
programs, and organized meetings with other persons with the condition.
Most patients are asymptomatic for years until the adenomas
are large and numerous, and cause rectal bleeding or even anemia, or cancer develops.
Without surgical intervention, FAP patients are nearly at a 100% risk of
developing colorectal cancer by the age of 45.
Original Source:- Familial Adenomatous Polyposis Market Research
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