SurVaxM Highlights: ASCO 2022
Positive results from the "SURVIVE" (Phase II a) research in people with newly discovered glioblastoma were given by Mimivax (Abstract #2037).
SurVaxM mechanism of action: Immunostimulants
A cell-survival protein found in 95 percent of glioblastomas and many other malignancies, survivin is the target of SurVaxM (MimiVax), a first-in-class, proprietary peptide mimic immunogen.
The SurVaxM immunotherapy for newly diagnosed glioblastoma Phase IIa (Survive) results was presented at ASCO 2022. A total of 63 patients with freshly diagnosed glioblastoma participated in the single-arm Survive research, with a median age of 60 for those who had just undergone their first round of chemoradiation. Each patient had a craniotomy, radiation therapy, and temozolomide treatment prior to receiving the SurVaxM priming dosages. It's interesting to note that, overall, 41 percent of patients survived for at least three years after receiving a glioblastoma diagnosis and 51 percent did so for at least two years. According to the study, patients receiving standard therapy do have a 16-month median chance of survival, and the patient did well with the immunotherapy plus temozolomide.
Giving people with glioblastoma greater survival is always a step in the right direction for such a rare but fatal malignancy. "It is really encouraging to see that many patients had their tumors respond to the combination of SurVaxM and temozolomide," We're thrilled to see this encouraging treatment advance to broader studies and research into possible uses or illness situations in other settings. - Expert Verdict.
Conclusion
We anticipate a shift in the standard of care for patients with newly diagnosed glioblastoma from a monotemozolimide regimen to a combination regimen in light of the positive results of the SurvaxM ASCO 2022 trial. Additionally, SurvaxM might provide a higher standard of living and longer survival.
Other medications, such as paxalisib (Kazia Therapeutics), Efflorithine+Lomustine (Orbus), regorafenib (Bayer), and many others are also being studied for GBM.
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